Localized Antimicrobial Delivery (Per Tooth) (D4381) — National Rates

Negotiated reimbursement rates for D4381 across 32 states, sourced from CMS Transparency in Coverage data. 184 rate records.

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National Average Negotiated Rate
$68
184 rate records · 32 states
📊 Data updated monthly · Last refresh: March 2026

About D4381 — Localized Antimicrobial Delivery (Per Tooth)

Localized Antimicrobial Delivery (Per Tooth) involves the application of antimicrobial agents directly into periodontal pockets to combat localized infections. This procedure is indicated for patients with specific periodontal issues where localized treatment is necessary. Proper documentation should include the specific teeth treated, the antimicrobial agent used, and the clinical rationale for its use. Reimbursement for this procedure averages around $68 but can vary widely by payor and state, with some plans requiring prior authorization or limiting coverage based on the severity of the periodontal condition.

Reimbursement rates for D4381 vary significantly by state, payor, and provider network. The national average negotiated rate is $68. Data sourced from CMS Transparency in Coverage machine-readable files, updated monthly.

Top Paying States for D4381

Iowa
$185
1 records
Colorado
$122
4 records
Florida
$106
27 records

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Full National Breakdown

Median
$62
Low
$20
High
$185

Highest & Lowest Reimbursement States

↑ Top 5

StateAvg Rate
Iowa$185
Colorado$122
Florida$106
New York$102
District of Columbia$100

↓ Bottom 5

StateAvg Rate
California$36
Minnesota$22
Kansas$20
Kentucky$20
New Mexico$20

All States — D4381 Average Rates

Iowa
$185
Colorado
$122
Florida
$106
New York
$102
District of Columbia
$100
Tennessee
$100
Alabama
$92
Massachusetts
$91
Pennsylvania
$89
Nevada
$80
Nebraska
$75
Utah
$72
Virginia
$68
Hawaii
$67
North Dakota
$62
Georgia
$61
Indiana
$61
Washington
$61
South Carolina
$61
New Jersey
$60
Connecticut
$58
Alaska
$58
Maryland
$55
Arizona
$54
Wisconsin
$47
Texas
$46
Louisiana
$38
California
$36
Minnesota
$22
Kansas
$20
Kentucky
$20
New Mexico
$20
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State-by-State Comparison Table

StateAverageMedianMinMaxRecords
Iowa$185$185$185$1851
Colorado$122$148$46$1484
Florida$106$95$89$12427
New York$102$77$20$15915
District of Columbia$100$100$100$1001
Tennessee$100$100$100$1001
Alabama$92$92$86$972
Massachusetts$91$100$60$1007
Pennsylvania$89$57$52$1593
Nevada$80$83$44$1128
Nebraska$75$75$75$751
Utah$72$73$64$764
Virginia$68$70$48$854
Hawaii$67$67$67$671
North Dakota$62$62$62$621
Georgia$61$61$51$712
Indiana$61$61$61$611
Washington$61$60$40$834
South Carolina$61$59$30$10613
New Jersey$60$43$41$1246
Connecticut$58$58$49$682
Alaska$58$58$58$583
Maryland$55$55$55$551
Arizona$54$49$31$766
Wisconsin$47$47$47$473
Texas$46$43$20$753
Louisiana$38$38$26$502
California$36$35$20$9027
Minnesota$22$20$20$5315
Kansas$20$20$20$201
Kentucky$20$20$20$201
New Mexico$20$20$20$201
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